By Miles Fisher, John J. McMurray
With heart problems changing into the commonest explanation for dying in individuals with diabetes, curiosity within the overview and therapy of middle ailment in those patients has been reawakened. This e-book examines constructing issues from a mostly cardiological perspective, covering both pharmacological and non-pharmacological interventions.
The DIGAMI examine at the use of intravenous insulin infusion on the time of myocardial infarction (MI) has motivated a number of dialogue papers at the most sensible therapy of MI within the diabetic patient. The UKPDS has proven that remedy of style 2 diabetes doesn't lessen cardiovascular end-points considerably, yet that competitive therapy of blood strain can do so. In addition, sub-group research from a number of huge cardiovascular trials has proven that therapy with statins, anti-platelet treatment, ACE inhibitors and different medicinal drugs also will decrease cardiovascular occasions in individuals with diabetes.
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Additional info for Diabetic Cardiology (Practical Diabetes)
Sample text
Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD (1996). Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. Journal of Clinical Investigation 97: 2601–10. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR (2000). Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. British Medical Journal 321: 405–12.
Annals of Internal Medicine 113: 909–15. Wever RM, Luscher TF, Cosentino F, Rabelink TJ (1998). Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circulation 97: 108–12. Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson D C, Creager MA (1998). Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 97: 1695–701. 36 ATHEROSCLEROSIS AND VASCULAR DISEASE IN TYPE 2 DIABETES Wilson PW, D’Agostino RB, Parise H, Sullivan L, Meigs JB (2005).
Similarly, when Caballero et al. 4). These findings suggest that vascular dysfunction may be an early feature of the insulin resistance syndrome. 4 Impaired endothelium-dependent vasodilation in people at risk for type 2 diabetes. The brachial artery diameter change in response to reactive hyperaemia also known as flowmediated dilation (endothelium-dependent vasodilation), is reduced in relatives of type 2 diabetic patients (Relatives), subjects with impaired glucose tolerance (IGT), and type 2 diabetic patients compared with healthy controls.