Data Mining for Genomics and Proteomics: Analysis of Gene by Darius M. Dziuda

By Darius M. Dziuda

Facts Mining for Genomics and Proteomics makes use of pragmatic examples and an entire case examine to illustrate step by step how biomedical reviews can be utilized to maximise the opportunity of extracting new and priceless biomedical wisdom from info. it's a superb source for college kids and pros concerned with gene or protein expression info in quite a few settings.

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Additional info for Data Mining for Genomics and Proteomics: Analysis of Gene and Protein Expression Data (Wiley Series on Methods and Applications in Data Mining)

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2007), and Vega (Wilming et al. 2008). 1 BASIC TERMINOLOGY 13 involving gene expression microarray data, we are interested in the gene expression level that refers to the number of copies of RNA transcripts created by transcription of a particular gene (for the protein-coding genes, this is the number of mRNA transcripts generated from the gene) at a given time. The genes that are expressed include the protein-coding genes as well as the genes coding for RNA functional products. Most often, the gene expression analysis focuses, however, on the expression level of the protein-coding genes.

Most often, the gene expression analysis focuses, however, on the expression level of the protein-coding genes. Although the same DNA is contained in every cell of an organism, cells of different tissues are different. The differences result from different levels of gene expressions, that is, different patterns of gene activations. If a gene is active (expressed), the protein (or proteins) encoded by the gene is (are) synthesized in the cell. The higher the gene expression level, the more of the protein is produced.

Here are a few examples of the concept of a gene as it was evolving in time (Gerstein et al. 2007; Rheinberger and Mu¨ller-Wille 2008). † A gene as a discrete unit of heredity that determines a characteristic of an organism as well as the heritability of this characteristic. † A gene as a stretch of DNA that codes for one protein. A gene as “a DNA segment that contributes to phenotype/function. In the absence of demonstrated function a gene may be characterized by sequence, transcription or homology” (Wain et al.

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