Chemical Genomics: Small Molecule Probes to Study Cellular by Stefan Jaroch (Editor), Hilmar Weinmann (Editor)

By Stefan Jaroch (Editor), Hilmar Weinmann (Editor)

Chemical genomics is a hugely interdisciplinary and extremely intriguing box of study either in lecturers and within the existence sciences undefined. The Ernst Schering examine origin Workshop fifty eight used to be prepared to collect clinical leaders within the box to debate the consequences of chemical genomics for drug discovery. a number of facets of the interface among chemistry and biology are lined during this quantity, reminiscent of chemogenomics efforts within the pharmaceutical undefined, diversity-oriented synthesis, chemogenomic techniques to the learn of mobile functionality, screening applied sciences, and normal items as instruments in chemical biology.

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22 of Methods and principles in medicinal chemistry. Mannhold R, Kubinyi H, Folkers G (eds) Wiley-VCH, Weinheim, pp 43–67 Kubinyi H, Müller G (eds) (2004) Chemogenomics in drug discovery – a medicinal chemistry perspective, vol. 22, Methods and principles in medicinal chemistry. Mannhold R, Kubinyi H, Folkers G (eds) Wiley-VCH, Weinheim Lipinski C, Hopkins A (2004) Navigating chemical space for biology and medicine. Nature 432:855–861 Lopez-Rodriguez ML, Morcillo MJ, Benhamu B, Rosado ML (1997) Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites.

Rouhi AM (2003) Moving beyond natural products. C&EN 81:104–107 Seidler J, McGovern SL, Doman TN, Shoichet BK (2003) Identification and prediction of promiscuous aggregating inhibitors among known drugs. J Med Chem 46:4477–4486 Slusarchyk WA, Robl JA, Taunk PC, Asaad MM, Bird JE, DiMarco J, Pan Y (1995) Dual metalloprotease inhibitors. V. Utilization of bicyclic azepinonethiazolidines and azepinonetetrahydrothiazines in constrained peptidomimetics of mercaptoacyl dipeptides. Bioorg Med Chem Lett 5:753– 758 Sneader W (1996) Drug prototypes and their exploitation.

48 50 52 53 56 58 59 59 Abstract. This article covers the diversity-oriented synthesis (DOS) of small molecules in order to generate a collection of pure compounds that are attractive for lead generation in a phenotypic, high-throughput screening approach useful for chemical genetics and drug discovery programmes. Nature synthesizes a rich structural diversity of small molecules, however, unfortunately, there are some disadvantages with using natural product sources for diverse small-molecule discovery.

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