Chemical and Pharmacological Perspective of Artemisia by Shabir H. Lone, Khursheed Ahmad Bhat, Mohammad Akbar Khuroo

By Shabir H. Lone, Khursheed Ahmad Bhat, Mohammad Akbar Khuroo

This publication reports the chemical and organic homes of Artemisia amygdalina Decne, a severely endangered and endemic plant species within the the high-altitude Kashmir Himalayas, which has a excessive pharmacological capability. It describes the bioactivity-guided isolation of its chemical substances, their characterization utilizing spectroscopic tools and the advance of an easy and trustworthy RP-HPLC process for the simultaneous quantification of the remoted ingredients. The authors speak about the capability pharmacological actions of A. amygdalina, resembling antioxidant, cytotoxic, anti inflammatory, immuno-modulatory and antidiabetic results, and pave the way in which for destiny research.

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Chemical and Pharmacological Perspective of Artemisia amygdalina

This booklet studies the chemical and organic houses of Artemisia amygdalina Decne, a significantly endangered and endemic plant species within the the high-altitude Kashmir Himalayas, which has a excessive pharmacological power. It describes the bioactivity-guided isolation of its chemical substances, their characterization utilizing spectroscopic tools and the advance of an easy and trustworthy RP-HPLC strategy for the simultaneous quantification of the remoted parts.

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11 shows the OGTT study; blood glucose concentration in all groups reached peak levels after 30 min of glucose administration (2 g/kg) and then began to decrease. As compared to normal group, the glucose levels of experimental rats treated with extracts and glibenclamide showed a steep reduction. ) showed more significant antihyperglycemic activity than other extracts and glibenclamide treated rats. 12).

The extracts have also shown reduction in the feed and water consumption of diabetic rats when compared with the diabetic control. H.  (2013). Different assays like DPPH assay, Riboflavin Photo-oxidation assay, Riboflavin Photooxidation assay, Ferric thiocyanate (FTC) assay, Thiobarbituric acid (TBA) assay, Post-mitochondrial supernatant (PMS) assay, and DNA–damage assay have been carried out. 06 µg mL−1), respectively, against DPPH radical. 1). 04 µg mL−1), respectively, against superoxide radicals.

59 (6H, m) suggested the presence of a cyclic spiroacetal unit that is common in natural acetylenes (Liang et al. 2011). 5] decane which was confirmed on comparison with literature (Bohlmann et al. 1973). Compound 6 has been isolated as a brown solid. 2 Hz compared to 16 Hz in Compound 4). This indication along with previous reports (Stavholt and Sorensen 1950) suggested that compound 6 was a cis-diastereomer of matricaria ester. 1 Bioactivity of the Extracts and Isolated Constituents Using SRB Assay The cytotoxic effect of hexane extracts of root and shoot as well as the isolates has been evaluated using Sulphorhodamine B (SRB) assay.

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