Case Studies in Lipid Management by D. John Betteridge

By D. John Betteridge

A definitive number of 35 case reviews written by way of opinion leaders within the box of lipid administration, this booklet offers subject matters of present curiosity starting from nutrition to the most recent pharmaceutical treatments. each one case is a hugely informative learn in accordance with each one contributor's personal own studies in the self-discipline of lipids. The ebook covers a number of probability components, sufferers with heart ailment, serious dyslipidemia, mixed hyperlipidemia, secondary lipidemia, and healing matters. It presents a essentially and resource for universal medical events and is a vital textual content for practitioners within the box and people in comparable professions.

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Often these patients are cared for by gynecologists only, and are not evaluated for potential cardiovascular risk soon enough. Weight loss and management of her insulin resistance are important. Her hepatic lipase abnormality and oral contraceptive therapy might fool the practitioner into underestimating her risk, given her elevated HDL-cholesterol and large LDL particle size. 9 If she was not considering pregnancy, low-dose statin therapy with a hydrophilic statin such as pravastatin or rosuvastatin might be appropriate, with a goal of bringing her LDL particle number down below 1000,10 and with the understanding that her benefit might be less than in those with elevated hepatic lipase levels.

Data in this area, however, have been conflicting. Hepatic lipase also has a ligand-binding function, and is involved in the function of the SRB-1 hepatic scavenger receptor role in reverse cholesterol transport (RCT). Low levels of hepatic lipase may interfere with RCT and affect cardiovascular outcomes adversely. Zambon et al. propose that cardiovascular risk is affected both by hepatic lipase activity levels and LDL-cholesterol levels6 (see Figure 1). This would account for her increased levels of large LDL particles, but would also suggest impaired RCT, and increased cardiovascular risk.

Now exactly 2 years later she leads a normal active life, does not smoke, and her blood pressure is 130/70 mm Hg. 5 mg, and aspirin 75 mg daily. qxd 7/24/2006 12:07 PM Page 17 CORONARY HEART DISEASE IN A PREMENOPAUSAL WOMAN risk factor should be judged in isolation. 0 mmol/l. It is important to treat each patient as an individual and not a statistic and to judge each case in the context of the mode of presentation and overall cardiovascular risk. 3 References 1. Mosca L, Appel LS, Benjamin EJ et al.

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