By Chandan K. Sen, Lester Packer, Patrick A. Baeuerle
This quantity addresses oxidant-reduction or redox and antioxidant delicate molecular mechanisms and the way they're implicated in several ailment techniques. attainable options to pharmacologically and/or nutritionally manage such redox-sensitive molecular responses are emphasised. Key Features:* Reactive species as intracellular messengers* Redox rules of mobile responses* scientific implications of redox signaling and antioxidant treatment
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1998) Klotz et al. (1998) Mendelson et al. (1996) Uchida et al. , not done. 1. , 1995). , 1998). Neither activation of JNK and p38 nor of NF-KB is, however, achieved employing the hydrophilic NDPO2 (Fig. , 1999). Thus, it is reasonable to suggest that the activation of JNK/p38 and proposedly AP-1 as well as of the NF-KB pathway by singlet oxygen relies on signal-integrating mechanisms in the cytosol, as 102 generated outside cells by NDPO2 or Rose Bengal-agarose is not sufficient for activation.
Circ. Res. 77, 29-36. , and Tyrrell, R. M. (1993). Singlet oxygen: A primary effector in the ultraviolet A/near-visible light induction of the human heme oxygenase gene. Cancer Res. 53, 45054510. Bonnett, R. (1995). Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy. Chem. Soc. Rev. 21, 19-33. , Klotz, L. , and Scharffetter-Kochanek, K. (1998). Central role of ferrous/ferric iron in the UVB-mediated signalling pathway leading to increased interstitial collagenase (MMP-1) and stromelysin1 (MMP-3) mRNA levels in cultured human dermal fibroblasts.
Water-soluble naphthalene derivatives as singlet oxygen (102, ~Ag)carriers for biological media. J. Photochem. Photobiol. B: Biol. 36, 31-39. Piette, J. (1991). Biological consequences associated with DNA oxidation mediated by singlet oxygen. J. Photochem. Photobiol. B: Biol. 11, 241-260. , and Piette, J. (1995). NF-KB transcription factor and human immunodeficiency virus type 1 (HIV-1) activation by methylene blue photosensitisation. Eur. J. Biochem. 228, 447-455. Pombo, C. , Bonventre, J. , Woodgett, J.