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Extra resources for Alginic acid : chemical structure, uses and health benefits
Sample text
There are different methodologies that can be carried out to obtain alginate gels using this principle [22]. g. ). All the physicochemical characteristics of alginate, together Alginate-Based Drug Carriers 19 with the biological properties, may be affected when these reactive functional groups are modified. Thus, alginate has become a very versatile polymer to be used in a lot of potential applications [28]. 3. Biological Properties All polymers used as drug delivery carriers in humans should display some important properties, such as biocompatibility and/or low immunogenicity.
An improvement of this synthesis consists of mixing the alginate gel microbeads with sericin, which is a silk protein [142]. Due to the importance of spinal cord injury it has been turned necessary to develop a method to diminish the damage in spinal cord lesions. Hydrogels are one of the possible materials to be used with this purpose because they can be injectable and can mimic the mechanical properties of native spinal cord tissue. When a spinal cord injury is produced cell lyses leads to an increase in extracellular Ca2+ and finally, it increases calcium dependent neuronal apoptosis.
Advanced Drug Delivery Reviews, 2012. 64: p. 194-205. [24] Rehm, B. H. , ed. Alginates: Biology and Applications. 2009, Springer. [25] Pawar, S. N. and K. J. Edgar, Chemical modification of alginates in organic solvent systems. Biomacromolecules, 2011. 12(11): p. 4095-103. , Evidence for egg-box-compatible interactions in calcium-alginate gels from fiber X-ray diffraction. Biomacromolecules, 2007. 8(7): p. 2098-103. [27] Draget, K. I. and C. Taylor, Chemical, physical and biological properties of alginates and their biomedical implications.