By Elio Riboli (auth.), Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione (eds.)
This booklet contains court cases from the 3rd foreign convention on Advances in meals and melanoma, held in Naples in may well 2012. This hugely multidisciplinary assembly analyzed “nutrition and melanoma” from varied views and at the foundation of certain and updated experimental ways. wisdom at the relation among way of life, nutrition, and melanoma is explored in a few contributions, and the position of nutritional intervention in melanoma sufferers is mentioned. problems with important curiosity to the study group, equivalent to epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of motion of usual compounds within the diet), obtain targeted attention. an additional key subject is the rising molecular applied sciences (the “omics”) that may solid gentle at the interaction among nutrients and human malignancies. Chapters take the shape of experiences that come with sections offering specialist opinions.
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Additional info for Advances in Nutrition and Cancer
The possible mechanisms through which adiponectin exerts anticancer effects may include increasing insulin sensitivity, and decreasing insulin/IGF-1 and mTOR signaling via activation of AMPK. Adiponectin also reduces proinflammatory cytokine expression via inhibition of the nuclear factor kappa-light-chainenhancer of activated B cells (NF-kB) [21–23]. In vitro, animal and epidemiologic evidence linking leptin [23–25] or adiponectin [21, 26–28] individually to cancer risk is mixed. Associations between the adiponectin-to-leptin ratio and the metabolic syndrome [29–31] and some cancers [32–34] are reported.
Obesity is associated with increased mortality from cancer of the prostate and stomach in men; breast (postmenopausal), endometrium, cervix, uterus, and ovaries in women; and kidney (renal cell), colon, esophagus (adenocarcinoma), pancreas, gallbladder, and liver in both genders . While the relationships between metabolic syndrome and specific cancers are less well established, first reports from the Metabolic Syndrome and Cancer Project, a European cohort study of approximately 580,000 adults, confirm associations between obesity (or BMI) in metabolic syndrome and risks of colorectal, thyroid, and cervical cancer .
Mirza S, Qu HQ, Li Q, Martinez PJ, Rentfro AR, McCormick JB, Fisher-Hoch SP (2011) Adiponectin/leptin ratio and metabolic syndrome in a Mexican American population. Clin Invest Med 34:E290 31. Labruna G, Pasanisi F, Nardelli C, Caso R, Vitale DF, Contaldo F, Sacchetti L (2011) High leptin/adiponectin ratio and serum triglycerides are associated with an ‘‘at-risk’’ phenotype in young severely obese patients. Obesity 19:1492–1496 32. Cleary MP, Ray A, Rogozina OP, Dogan S, Grossman ME (2009) Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention.