Acromegaly: Pathology, Diagnosis and Treatment by Aart Jan van der Lely, Albert Beckers, Adrian Daly, Steven

By Aart Jan van der Lely, Albert Beckers, Adrian Daly, Steven W. Lamberts, David R. Clemmons

This ebook reports the pathophysiology and actual manifestations of acromegaly and discusses the a number of remedies now on hand for the administration of the sufferer with acromegaly. The publication includes an plentiful variety of illustrations that support to stress issues of specific curiosity, together with radiological, histopathological, and actual prognosis pictures. Sections are dedicated to detailing vital subject matters together with determinants of pathological results of sickness job in acromegaly, person healing offerings and standards for prognosis, and disorder keep watch over.

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13. Barkan AL, Dimaraki EV, Jessup SK, Symons KV, Ermolenko M, Jaffe CA. Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. J Clin Endocrinol Metab 2003; 88(5):2180–2184. 14. van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004; 25(3):426–457. 15. Popovic V, Miljic D, Micic D, Damjanovic S, Arvat E, Ghigo E, Dieguez C, Casanueva FF.

Beckers 47 48 I. Pathology Figure 12 Electron micrograph of somatomammotroph cells stained simultaneously for GH (15 nm particles) and prolactin (10 nm particles). Both hormones are present in the same granules. Source: A. Beckers Figure 13 Electron micrograph showing double-gold immunostain in a mixed GH/prolactin-secreting pituitary adenoma. A prolactin-secreting cell is shown on the left, while a GH-secreting cell is on the right. Source: A. Beckers 3. Epidemiology, Pathology, and Complications 49 Figure 14 Pituitary hyperplasia due to the effects of a GHRH-secreting carcinoid tumor associated with GH hypersecretion and acromegaly.

Cushing H. Partial hypophysectomy for acromegaly; with remarks on the function of the hypophysis. Ann Surg 1909; 50:1002–1017. 26. Liu JK, Das K, Weiss MH, Laws ER, Couldwell WT. The history and evolution of transsphenoidal surgery. J Neurosurg 2001; 95:1083–1096. 27. Lanzino G, Laws ER. Pioneers in the development of transsphenoidal surgery: Theodor Kocher, Oskar Hirsch, and Norman Dott. J Neurosurg 2001; 95:1097–1103. 28. Hardy J, Wigser SM. Trans-sphenoidal surgery of pituitary fossa tumors with televised radiofluoroscopic control.

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