A Short History of the Drug Receptor Concept (Science, by Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis

By Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell

The receptor notion used to be some of the most influential principles in 20th-century drugs since it may possibly account for the hugely particular results of substances at the physique. This ebook is the 1st to supply an historic dialogue of its beginning, improvement, sluggish attractiveness into pharmacology and next influence on sleek drugs. It additionally considers the social context that stimulated the drug receptor's development., creating a worthy contribution to the historical past and figuring out of contemporary medication.

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At this point one has to consider that the impact of Landsteiner’s immunological theory on Ehrlich’s second shift of interests is questionable. 132 Despite Ehrlich’s enthusiasm about receptors, there are indications in his correspondence that he was not entirely satisfied with his situation. 135 Even in his immunological studies he did not hesitate to draw parallels with staining processes. Ehrlich was not very keen to work as a physician again, but he wanted to carry out clinical testing of potential drugs.

Although giving him credit for new findings in the field of immunology, Gruber attacked Ehrlich’s substance-binding theories of specific toxins and immune bodies in a very polemic way, as purely speculative with a nearly total lack of evidence. For Gruber, many immunological phenomena were still unexplained and applying Ehrlich’s theory to the solution of specific problems represented no more than a logical game. 115 Again, Ehrlich made tremendous efforts to explain to his academic friends the weakness of Gruber’s criticism.

The images themselves fuelled the criticism of opponents, as they were an attempt by Ehrlich to illustrate invisible structures whose material existence was not evident but debated at this time. 124 Remarkably enough, Ehrlich’s efforts to consolidate the receptor theory were supported in the realm of literary fiction. One of the few things Ehrlich did in his leisure time was to read detective stories, especially those of Sir Arthur Conan Doyle (1859–1930). 125 The ideas of his teacher Robert Koch flooded back into his mind through the reading of poetry.

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