By Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell
The receptor notion used to be some of the most influential principles in 20th-century drugs since it may possibly account for the hugely particular results of substances at the physique. This ebook is the 1st to supply an historic dialogue of its beginning, improvement, sluggish attractiveness into pharmacology and next influence on sleek drugs. It additionally considers the social context that stimulated the drug receptor's development., creating a worthy contribution to the historical past and figuring out of contemporary medication.
Read or Download A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History) PDF
Best history_1 books
Guynn deals an leading edge new method of the moral, cultural, and ideological research of medieval allegory. operating among poststructuralism and old materialism, he considers either the playfulness of allegory (its openness to a number of interpretations and views) and its disciplinary strength (the use of rhetoric to naturalize hegemonies and suppress distinction and dissent).
The realm courtroom Digest maintains the Fontes Iuris Gentium, a sequence that provides the selections of the everlasting court docket of foreign Justice and the overseas court docket of Justice as much as 2000. the recent quantity covers the interval from 2001 to 2005. All very important pronouncements of the courtroom in its judgments and advisory reviews are systematically prepared less than particular issues taken from important and procedural overseas legislation.
- From Political Economy to Freakonomics: Method, the Social and the Historical in the Evolution of Economic Theory (Economics As Social Theory)
- Pierre Bayle: Tome II Heterodoxie et Rigorisme
- The exchequer rolls of Scotland. Volume III, 1379-1406: Rotuli scaccarii regum Scotorum
- Motion Graphic Design: Applied History and Aesthetics, 2nd Edition
- The History of the International Polar Years (IPYs)
Additional info for A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History)
At this point one has to consider that the impact of Landsteiner’s immunological theory on Ehrlich’s second shift of interests is questionable. 132 Despite Ehrlich’s enthusiasm about receptors, there are indications in his correspondence that he was not entirely satisfied with his situation. 135 Even in his immunological studies he did not hesitate to draw parallels with staining processes. Ehrlich was not very keen to work as a physician again, but he wanted to carry out clinical testing of potential drugs.
Although giving him credit for new findings in the field of immunology, Gruber attacked Ehrlich’s substance-binding theories of specific toxins and immune bodies in a very polemic way, as purely speculative with a nearly total lack of evidence. For Gruber, many immunological phenomena were still unexplained and applying Ehrlich’s theory to the solution of specific problems represented no more than a logical game. 115 Again, Ehrlich made tremendous efforts to explain to his academic friends the weakness of Gruber’s criticism.
The images themselves fuelled the criticism of opponents, as they were an attempt by Ehrlich to illustrate invisible structures whose material existence was not evident but debated at this time. 124 Remarkably enough, Ehrlich’s efforts to consolidate the receptor theory were supported in the realm of literary fiction. One of the few things Ehrlich did in his leisure time was to read detective stories, especially those of Sir Arthur Conan Doyle (1859–1930). 125 The ideas of his teacher Robert Koch flooded back into his mind through the reading of poetry.